Endocrine Abstracts

Background: Hyperuricemia is often associated with chronic kidney diseases (CKD) and is considered as an independent risk factor of cardiovascular and renal diseases. Urate transporter 1 (URAT1), organic anion transporter 1 (OAT1) and OAT3 are believed to play pivotal roles on urate excretion in kidneys. Activation of RAAS in the kidney plays a key role in the pathophysiology of CKD. Thus, we hypothesized that RAAS may be involved in hyperuricemia in patients with CKD by effec...

Aldosterone play pivotal roles on renal fibrosis by inducing mesangial cells proliferation and stimulating collagen synthesis in renal fibroblasts. However, whether renal proximal tubules are involved in aldosterone-induced renal fibrosis is not yet identified. The aim of this study was to examine the potential role of aldosterone in collagen expression via activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) in cultured human renal proximal tubular epit...